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13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [5-, 17-, and 59-fold the maximum recommended human dose (MRHD) of 1 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (2-, 5-, and 17-fold MRHD) were administered to the females

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From something in the air to something in the brain As early as 1833, people already had some sense about how olfaction, the sense of smell, works: Olfaction , the sense, by which we perceive the impressions made on the olfactory nerves by the odorous particles suspended in the atmosphere (R

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Patients were screened to include only those who were GLP-1RA-nave, defined as having no recorded GLP-1RA purchases during the 365-day pre-index period, in the final analytical dataset

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